Speaker: Kory J. Lavine, MD, PhD, Associate Professor of Medicine, Center for Cardiovascular Research, Director of Cardiovascular Precision Medicine Research Initiative, Washington University School of Medicine in St. Louis

Talk Title: Unraveling Immune Cell Diversity and Function within the Heart

Abstract: Innate immunity is a critical regulator of cardiac development, heart failure progression, and myocardial tissue repair. Within these contexts, functionally and ontologically distinct macrophage populations reside within the myocardium and are essential determinants of outcomes following tissue injury or during chronic disease. The human and mouse heart contains two distinct sets of macrophages with divergent inflammatory and tissue reparative functions. During the presentation, I will discuss a novel function of tissue resident macrophages in adaptive tissue remodeling through sensing of mechanical cues.  In addition, I will discuss the identities, functions, and newly identified effector mechanisms of inflammatory cardiac macrophages. Lastly, I will discuss precision medicine based approaches for clinical translation.

Time: 1pm-2pm PDT (3PM CST)

Zoom Password: 294085